Oleanolic acid kika kya pentacyclic triterpenoids ekifunibwa nga twawula n’okuggya mu bibala by’ekimera kyonna eky’ekimera kya Gentianaceae, ekika ky’ekika kya Syringa japonica oba Ligustrum lucidum. Okunoonyereza ku ddagala okw’omulembe kukakasizza nti asidi wa oleanolic asobola okukendeeza ennyo ku bugulumivu bwa serum alanine aminotransferase, okukendeeza ku kuvunda kw’obutoffaali bw’ekibumba n’okufa, enkola y’okuzimba ebitundu by’ekibumba n’enkola ya fibrosis, okutumbula okuddamu okuzimba obutoffaali bw’ekibumba, okwanguya okuddaabiriza ebitundu by’ekibumba ebifudde, okuziyiza Non-specific inflammatory response, era alina ekikolwa eky’okutereeza enkyukakyuka ya puloteyina obuzibu. Okwetegereza kwa ultrastructural kulaga nti oleanolic acid esobola okukuuma n’okutebenkeza oluwuzi lwa lysosomal ne biofilm y’ebitundu by’omubiri, okuzzaawo obutafaali bwayo obutakola n’emirimu gyayo egy’entambula, okuzzaawo entambula ya ion n’amazzi mu butoffaali n’ebweru w’obutoffaali, n’okusumulula cytoplasm ne balloon-nga hepatocytes zidda mu mbeera eya bulijjo, obusobozi bw’okuddamu okukola neyongera, ne liver fibrosis kiziyizibwa era ne kiziyizibwa. Okugezesa mu vitro kwalaga nti oleanolic acid asobola okuziyiza okukula kw’obutoffaali bwa leukemia nga akendeeza ku kwolesebwa kw’ensonga y’okukula kw’emisuwa endothelial. Kisaanira okujjanjaba obulwadde bw’ekibumba obuva ku kawuka, era kisobola okulongoosa obubonero, obubonero n’enkola y’ekibumba, okutereeza obuzibu mu nkyukakyuka ya puloteyina n’okuba n’ebikolwa ebimu ebiziyiza-ebizimba.
Mu by’obukuumi, abatonotono baafuna akamwa akakala, ekiddukano, n’obutabeera bulungi mu lubuto olwa waggulu oluvannyuma lw’okumira asidi wa oleanolic, eyabula oluvannyuma lw’okujjanjabwa obubonero. Okukendeera kw’obutoffaali obutono (mild thrombocytopenia) kubaawo mu mbeera ssekinnoomu, eziyinza okuwona oluvannyuma lw’okuyimiriza eddagala.
Matrine kika kya alkaloid ekiggibwa ne kyawulwa mu Sophora japonica, ekimera eky’ekika kya Sophora, okusinga oxymatrine, era kirimu oxymatrine entono. Matrine erina ekikolwa eky’okwongera ku leukocytes, era era erina ekikolwa ekyeyoleka eky’okuwonya ku leukopenia; kirina obukuumi ku buvune bw’ekibumba, serum alanine aminotransferase ekendeera, okufa kw’ekibumba n’okuzimba bikendeera, n’okuddaabiriza ebitundu by’ekibumba kweyongera; okugezesa mu vitro ne mu vivo kulaga nti, Kirina ekikolwa ekimu eky’okuziyiza okuddiŋŋana kw’akawuka ka hepatitis B; kiyinza okukendeeza ku kuyita kw’emisuwa, okuziyiza okukula kw’ebitundu by’omubiri ebiyitibwa granulation tissue, okulungamya okufuluma kwa histamine, leukotrienes n’abatabaganya abalala okuva mu butoffaali bw’ekibumba, n’okuziyiza okufulumya obutoffaali obuyitibwa leukocytes okuva mu lipopolysaccharide-induced mouse peritoneal macrophages. Cytokines nga IL-1, interleukin-6, tumor necrosis factor- , n’ebirala, zirina ebikolwa ebitali-steroidal hormone-nga anti-inflammatory ne anti-allergic effects; esobola okuziyiza okukula kw’obutoffaali obuyitibwa hepatic stellate cells era n’ekola anti-hepatic fibrosis effects; Immunomodulatory effect, era esobola bulungi okuziyiza oba okulwawo okubeerawo kwa kookolo w’ekibumba. Kisaanira okujjanjaba obulwadde bwa hepatitis B obutawona, hepatitis B fibrosis, leukopenia obuva ku tumor radiotherapy, chemotherapy n’obulwadde bwa leukopenia obuva ku nsonga endala. Obujjanjabi obuyamba ku bulwadde bwa eczema obw’amaanyi n’obutawona n’obulwadde bwa herpes zoster.
Mu by’obukuumi, ekizibu ekitera okuva mu matrine kwe kweyongera okw’akaseera katono mu alanine aminotransferase, ekiyinza okulongoosebwa n’eddagala erigenda mu maaso. Wayinza okubaawo okuziyira, okusiiyibwa, okuwooma okukaawa, ekiddukano, obutabeera bulungi oba obulumi mu lubuto n’ebirala Oluusi n’oluusi, okusiiyibwa kw’olususu, okunyiga mu kifuba, n’omusujja biyinza okubaawo, era okutwalira awamu obubonero obwo waggulu bwe buwummuza.
Silibinin kirungo kya antioxidant, ekiggibwa mu kimera ekiyitibwa milk thistle, ekisobola okutebenkeza obuwuka bw’obutoffaali bw’ekibumba, okukuuma enkola y’enziyiza y’obutoffaali bw’ekibumba, okuggyawo ebirungo bya oxygen ebikola mu butoffaali bw’ekibumba, bwe kityo ne kyongera ku busobozi bw’ekibumba okuggya obutwa mu kibumba, Okulongoosa enkola y’ekibumba n’okutumbula okuddamu okuzimba obutoffaali bw’ekibumba. Ebivudde mu kukebera eddagala n’obutwa biraga nti silibinin erina diguli ez’enjawulo ez’obukuumi n’obujjanjabi ku bika eby’enjawulo eby’okwonooneka kw’ekibumba okuva ku butwa bw’ekibumba, eddagala eriziyiza-akafuba, sepsis, n’ebirala, era asobola okuziyiza okulinnya kwa aminotransferase okutuuka ku ddaala eritali limu. ddirira. Ebivudde mu kukebera biraga nti silibinin esobola okuziyiza okukula kw’obutoffaali bw’ekibumba n’okukola kolagini, erina ekikolwa ekimu ekiziyiza-fibrotic, esobola okuziyiza ebizibu bya sukaali ng’eyongera ku lipid peroxide clearance, era esobola okwongera ku insulin sensitivity in vivo. Kisaanira okujjanjaba enkola y’ekibumba etali ya bulijjo mu kwonooneka kw’ekibumba okw’obutwa n’abaserikale b’omubiri, obulwadde bw’ekibumba obw’amaanyi n’obutawona, n’ekibumba ekirimu amasavu olw’omwenge. Era okuba n’obuziyiza obumu obw’obulwadde bw’ekibumba obuyitibwa liver fibrosis. Kirina ebimu ku bikolwa eby’okuziyiza n’okujjanjaba ku bizibu bya sukaali n’endwadde ezikwatagana n’okuziyiza insulini-. Bwe kikozesebwa okujjanjaba ekibumba ekirimu amasavu n’obulwadde bw’ekibumba, kirungi obutalya mmere erimu amasavu mangi-. Obujjanjabi obw’okuddaabiriza busobola okukozesebwa okujjanjaba okwonooneka kw’ekibumba okuva ku kunywa omwenge n’okunywa sigala okumala ebbanga eddene-.
